Aims & Scope

Journal of Respiratory Diseases (JRD) publishes mechanistic research elucidating the molecular and cellular pathophysiology of respiratory diseases, from biomarker discovery to disease pathway analysis.

Disease Mechanisms Molecular Pathways Biomarker Discovery Cellular Pathophysiology Disease Models

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Core Research Domains

Inflammatory Lung Disease Mechanisms

Molecular pathways in asthma pathogenesis
COPD inflammatory cascade mechanisms
Cytokine signaling in chronic bronchitis
Epithelial-mesenchymal transition in airway remodeling
Oxidative stress pathways in lung inflammation
Immune cell dysfunction in bronchiectasis

Typical Fit Example "Identification of novel IL-17 signaling intermediates driving neutrophilic inflammation in severe asthma through single-cell RNA sequencing"

Fibrotic Disease Pathophysiology

Molecular mechanisms of idiopathic pulmonary fibrosis
Fibroblast activation pathways in lung scarring
Extracellular matrix remodeling mechanisms
TGF-β signaling in pulmonary fibrosis
Epithelial injury and repair mechanisms
Senescence pathways in fibrotic lung disease

Typical Fit Example "Characterization of myofibroblast differentiation pathways and identification of targetable kinases in progressive pulmonary fibrosis using proteomics"

Respiratory Infection Pathogenesis

Host-pathogen interaction mechanisms in pneumonia
Viral entry and replication pathways in respiratory epithelium
Innate immune response mechanisms to respiratory pathogens
Bacterial virulence factor mechanisms in lung infection
Immune evasion strategies of respiratory pathogens
Molecular basis of tuberculosis granuloma formation

Typical Fit Example "Mechanistic analysis of SARS-CoV-2 spike protein interaction with ACE2 receptor and downstream inflammatory signaling cascades in alveolar cells"

Pulmonary Vascular Pathobiology

Molecular mechanisms of pulmonary hypertension
Endothelial dysfunction pathways in vascular remodeling
Smooth muscle cell proliferation mechanisms
Hypoxia signaling in pulmonary vasculature
Thrombotic pathway activation in pulmonary embolism
Angiogenesis dysregulation in vascular lung diseases

Typical Fit Example "Identification of endothelin-1 signaling intermediates driving pulmonary arterial smooth muscle proliferation through phosphoproteomics analysis"

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Secondary Focus Areas

Biomarker Discovery & Validation

Identification and mechanistic characterization of molecular biomarkers for respiratory disease diagnosis, prognosis, and mechanistic stratification. Focus on pathway-linked biomarkers with mechanistic rationale.

Disease Model Development

Development and characterization of in vitro, ex vivo, and animal models that recapitulate respiratory disease pathophysiology. Emphasis on mechanistic validation and translational relevance.

Occupational Lung Disease Mechanisms

Molecular pathways underlying silicosis, asbestosis, and hypersensitivity pneumonitis. Focus on particle-induced cellular responses, inflammation mechanisms, and fibrotic pathway activation.

Rare Lung Disease Pathophysiology

Mechanistic studies of sarcoidosis, lymphangioleiomyomatosis (LAM), and other rare interstitial lung diseases. Emphasis on unique molecular pathways and disease-specific mechanisms.

Sleep-Disordered Breathing Mechanisms

Molecular and cellular mechanisms underlying obstructive sleep apnea, including intermittent hypoxia signaling, inflammatory pathway activation, and cardiovascular consequences at the molecular level.

Lung Cancer Pathobiology

Molecular mechanisms of lung carcinogenesis, tumor microenvironment interactions, metastatic pathway activation, and resistance mechanisms. Focus on pathophysiological understanding rather than clinical oncology.

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Emerging Research Frontiers

Selective Consideration with Enhanced Editorial Review

Single-Cell Omics in Lung Disease Mechanistic insights from single-cell transcriptomics, proteomics, and spatial profiling revealing cellular heterogeneity in respiratory pathophysiology.

Epigenetic Mechanisms DNA methylation, histone modifications, and non-coding RNA regulation in respiratory disease pathogenesis and progression.

Microbiome-Host Interactions Molecular mechanisms by which respiratory microbiome alterations influence lung disease pathophysiology through immune modulation and metabolic pathways.

Mitochondrial Dysfunction Mitochondrial pathway dysregulation, oxidative phosphorylation defects, and metabolic reprogramming in respiratory disease mechanisms.

Mechanobiology of Lung Disease Mechanical force sensing, mechanotransduction pathways, and biomechanical stress responses in respiratory pathophysiology.

AI-Driven Pathway Discovery Machine learning approaches for identifying novel disease mechanisms, pathway interactions, and molecular signatures from multi-omics datasets.

Note: Emerging area submissions undergo additional editorial assessment to ensure strong mechanistic focus and alignment with journal scope.

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Article Types & Editorial Priorities

Priority 1 - Fast Track

Expedited Review (4-6 weeks)

Original Research Articles Systematic Reviews & Meta-Analyses Methods & Protocols Mechanistic Studies

Priority 2 - Standard

Regular Review (6-8 weeks)

Short Communications Data Notes Technical Notes Perspectives Hypothesis Articles

Selective Consideration

Enhanced Editorial Assessment

Case Reports (mechanistic focus required) Opinion Pieces (by invitation) Commentaries (by invitation)

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Editorial Standards & Requirements

Reporting Guidelines

ARRIVE 2.0 for animal studies
MIQE for qPCR experiments
PRISMA for systematic reviews
STROBE for observational studies
CONSORT for clinical trials (if mechanistic)

Data Transparency

Raw data deposition in public repositories
Omics data in GEO, ArrayExpress, or ProteomeXchange
Code availability for computational analyses
Reagent and resource sharing statements
Reproducibility documentation required

Ethics & Integrity

IRB/Ethics committee approval for human samples
IACUC approval for animal studies
Informed consent documentation
Conflict of interest disclosure
Adherence to COPE guidelines

Preprint Policy

Preprint posting encouraged (bioRxiv, medRxiv)
Does not affect consideration for publication
Must be disclosed during submission
Version control maintained
Preprint DOI linked in final publication

Ready to Submit Your Research?

If your work elucidates molecular mechanisms of respiratory disease pathophysiology, we want to hear from you. Questions about scope fit? Contact our editorial team before submission.

Contact Editorial Office

Journal of Respiratory Diseases

Journal of Respiratory Diseases – Aim And Scope