Shumei Song

Address:

1515 Holcombe Blvd,
Unit 0426,
Houston, TX, 77030
United States

Research Interests:

esophageal and gastric cancer research, biomarkers and molecular pathogenesis

Biography:

BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.

NAME
Song, Shumei    POSITION TITLE
Assistant Professor
eRA COMMONS USER NAME (credential, e.g., agency login)
SHUSONG    
EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION    DEGREE
(if applicable)    MM/YY    FIELD OF STUDY
Binjou Medical College, Binjou, China    M.D.    1981-1986    Medicine
Wuhan University, Wuhan, China    M.S.    1986-1989    Histoembryology
Beijing University, Beijing, China    PH.D.    1996-1999    
Biochemistry and Molecular Biology
The U.T. M.D. Anderson Cancer Center, Houston, TX    POSTDOC    1999-2004    Cancer Biology
            
A.    Personal Statement
I have has been carrying out research on gastrointestinal cancers especially focus on esophageal adenocarcinoma research for more than ten years. I have extensive experience in gastrointestinal cancer biology, gene transcription and expression regulation, and molecular approaches to investigations of cellular mechanisms of esophageal cancer initiation, transformation and progression as evidenced by my publications. During my postdoctoral fellow training period, I started to direct my efforts to understand processes involved in the initiation and progression of adenocarcinoma of the esophagus. As one of the least studied and deadliest cancers in the US; we see its incidence increasing rapidly. The data independently generated in esophageal cancer led me to receive the prestigious AGA Research Scholar Award and DDC award and many publications and presentations in the national and international level in the field of esophageal adenocarcinoma. Recently, I have focused on aberrant stem cell signaling including Hippo,TGF-, Wnt and Hedgehog signaling in the pathogenesis of Esophageal and Gastric cancers as well as mediating chemo-resistance and identify biomarkers for targeting therapy. 

B.    Positions and Honors
 Positions and Employment
POSITIONS 
1989-1992 Research Assistant, Cancer Biology, Hubei Cancer Institute, Wuhan, China. 
1992-1996 Assistant Professor, Hubei Cancer Institute, Wuhan, China. 
2004-2008 Instructor, Univ. of Texas M.D Anderson Cancer Center, Houston. 
2008-Present Assistant Professor, Univ. of Texas M.D Anderson Cancer Center, Houston. 
HONORS AND AWARDS 
2001            Outstanding Graduate Student Award, Beijing University, Beijing
2001            Advanced research award in science and technique, Beijing
2005             International Society of Gastrointestinal Oncology, Washington DC; Travel Award
2007            Texas Medical Center Digestive Disease Center (DDC), Houston, TX; Pilot Award
2007            4th annual international society of gastrointestinal oncology, Philadelphia, PA
                    Travel Award and speaker.
2007            Rising Star Award and invited speaker in the United European Gastroenterology Week,
                    Paris, France
2008            2nd Japan & US Collaboration Conference in Gastroenterology (JUCC), Tokyo, Japan
                    Travel Award and invited speaker.
2008            5th annual international society of gastrointestinal oncology meeting (ISGIO),Washington DC
                    Travel Award and speaker.
2006-2010    Foundation for Digestive Health & Nutrition from American Gastroenterology Association, AGA
                    Research Scholar Award

 

2010-2012   Texas Medical Center Digestive Disease Center (DDC), Houston, TX Pilot Award
2011-2014   UT MD Anderson Cancer Center, Houston, TX; Cyrus Scholar Award and Plaque in 
                    Basic/Translational Research

Professional Societies
2000-pres Member of American Association for Cancer Research (AACR)
2004-pres Member of American Gastroenterology Association (AGA)
2005-pres Member of International Society of Gastrointestinal Oncology (ISGO)
2006-pres Member of Texas Medical Center Digestive Disease Center (DDC), Houston, Texas
2010-pres Member of the American Association for the Study of Liver Diseases (AASLD)

C.    Selected peer‐reviewed publications, in chronological order (earliest to recent). 

1.    Song S, Chen M. Cancer of autoplastic cervix and vagina induced with Herpes Simplex Virus type2 in mice. Journal China Experimental and clinical Virology 6:227-232, 1992
  2.    Li J, Song S. LAK cells from abdominal ascites treating a case of hepatic cancer. Cancer Research of Prevention and Treatment 21:98-99, 1994
  3.    Song S et al. Examination of HSV-2 antigen in autoplastic cervical cancer and proliferated tissue in mice. Cancer Research of Prevention and Treatment 22:144-145, 1995
  4.    Song S, Shou C. Molecular-biology research progression of VEGF and VEGF receptor. Foreign Medical Molecular Biology Fascicle 19:245-250, 1997
  5.    Song S Shou C. Telomerase---the new target for cancer therapy. Foreign Medical Oncology Fascicle 17:86-89, 1997
  6.    Song S, Wu J, Shou C. Expression of VEGF Receptor II, KDR, in Different Originated Carcinoma. Chinese Journal of Cancer Research 10:104-108, 1998
  7.    Song S, Shou C. Molecular cloning and prokaryotic expression of Vascular Endothelial Growth Factor Receptor KDR. Journal of Chinese Biochemistry and Molecular Biology 14:57-6, 1998
  8.    Song S, Wu J, Shou C. The Preparation and Identification of Monoclonal Antibodies against Vascular endothelial Cell Growth Factor Receptor (KDR) . Journal of Beijing Medical University 30:509-511, 1998
  9.   Song S, Shou C. Cloning and Expression of Truncated KDR Binding to Vascular Endothelial Growth. Prog. Biochem. Biophys. 26:481-484, 1999
 10.   Song S, Zeng L, et al. Cloning and McAb Preparation of VEGF Receptor KDR Extracellular V-VII domains and its expression in Different Originated Tumors. Chinese Journal of Oncology 21:96-98, 1999
 11.   Song S, Wu J, Shou C. Inhibition of Monoclonal Antibodies against Extracellular I-IV domains of Vascular Endothelial Cell Growth Factor Receptor KDR on the Proliferation EC and Formation of Chicken embryo blood Vessels. Chin J Microbiol Immunol 20:327-330, 2000
 12.   Song S, Shou C. Inhibition of prokaryotic expressed soluble KDR receptor on activity of Vascular Endothelial Growth Factor. Natl Med J China 80:226-227, 2000
13    Tian X, Song S, Wu J, Meng L, Dong Z, Shou C. Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun 286:505-12, 8/2001
14    Song S, XU XC. Effect of Benzo[a]pyrene Diol Epoxide on Expression of Retinoic Acid Receptor- in Immortalized Esophageal Epithelial Cells and Esophageal Cancer Cells. Biochemical and Biophysical Research Communications 281, 872–877, 2001. 
15    Lei H, An P, Song S, Liu X, He L, Wu J, Meng L, Liu M, Yang J, and Shou C. A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular  Endothelial Growth factor to its Kinase Domain Receptor. J. Bio Chem. 277: 43137-43142, 2002. 
16     Li M, Song S, Lippman SM, Zhang X, Lotan R, Xu XC. Induction of retinoic acid receptor- suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene. 21, 411-418, 2002. 
 17.  Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM. Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. Neoplasia 5:121-7, 3/2003

 18.   An P, Lei H, Zhang J, Song S, He L, Jin G, Liu X, Wu J, Meng L, Liu M, Shou C. Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer 111:165-73, 8/2004
 19.   Song S, Byrd JC, Koo JS, Bresalier RS. Bile acids induce MUC2 overexpression in human colon carcinoma cells. Cancer 103:1606-14, 2005
 20.   Song S, Byrd JC, Mazurek N, Liu K, Koo JS, Bresalier RS. Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. Gastroenterology 129:1581-91, 2005
 21.  Song S, Lippman SM, Zou Y, Ye X, Ajani J, and Xu XC. Induction of Cyclooxygenase-2 by Benzo[a]pyrene Diol Epoxide through Inhibition of Retinoic Acid Receptor-β expression Esophageal Cancer Cells. Oncogene. 24(56): 8268-8276, 2005. 
22.  Song S, Guha S, Liu K-F, Buttar N.S, and Bresalier RS. COX-2 Induction by Unconjugated Bile Acids Involves Reactive Oxygen Species-Mediated Signaling Pathways in Barrett's Oesophagus and Oesophageal Adenocarcinoma. Gut. 56(11):1512-1521, 2007. 
23.  Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3 beta activity. Cancer Res. 69(4):1343-9, 2009. 
24.  Song S, Krishnan K, Liu KF, Bresalier RB. Polyphenon E Inhibits the Growth of Human Barrett’s and Aerodigestive Adenocarcinoma Cells by Suppressing Cycin D1 Expression. Clinical Cancer Research 15(2):6-31, 2009. 
25.  Song S, Guan B, Men T, Hoque A, Lotan R, Xu XC. Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. Cancer Prev Res 2(3):274-80, 2009. 
26.  Song S, Byrd JC, Guha S, Liu K-F, Koul D, Bresalier RS. Induction of MUC5AC mucin by conjugated bile
       acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase B/activator protein-1
     pathway. Cancer. 2011;117:2386-2397.
27.  Mendelson J#, Song S#, Li Y, Mishra B, Davila M, Hofstetter W, Mishra L. Disfunctional TGF-β signaling
     with constitutively active notch signaling in Barrett's esophageal adenocarcinoma. Cancer.
     2011;117(16):3691-3702. #These authors contributed equally.
28. Song S*, Mishra L*. Reply to Disfunctional TGF- signaling with constitutively active Notch
      signaling in Barrett’ esophageal adenocarcinoma. Cancer. 2011 Sep.6. [Epub ahead of print]. * Co-
       corresponding author
29. Song S*, Ji B, Ramachandran V, Mazurek M, Wang H, Logsdon C, Bresalier RS. Galectin-3
     Induces Cell Proliferation and Invasion by Binding K-Ras and Activating RAS Signaling in Pancreatic
     Cancer Cells. PLoS ONE, 2012; 7(8):e42699 * corresponding author.
30. Song S and Ajani J A. The role of microRNAs in cancers of the upper gastrointestinal tract. Nat. Rev.
      Gastroenterol. Hepatol. 2013,10:109-118. 
31. Song S*, Maru DM, Ajani JA, Chan CH, Honjo S, Lin HK et al Correa A, Hofstetter WL, Davila M,
     Stroehlein J, and Mishra L. Loss of TGF- Adaptor 2SP Activates Notch Signaling and SOX9
     Expression in Esophageal Adenocarcinoma. Cancer Res., 2013 Apr 1; 73(7):2159-69. * Corresponding
     author.
 32. Wadhwa R, Song S, Yao Y, Lee J-S, Wei Q and Ajani JA. Gastric Cancer: Molecular and Clinical Dimensions. Nature Reviews Urology & Nature Reviews Clinical Oncology; 2013, in press.
 33. Song S, Ajani JA, Honjo S Maru DM, Scott A, Yao Y, Hung MC and Johnson RL The Hippo Coactivator
      YAP1 Upregulates SOX9 and Endows Cancer Stem Cell Properties in Non-Tumorigenetic Cells and
      Esophageal Cancer Cells. Nature Medicine, 2013 submitted. * Corresponding author.                           

D.     Research Support 

Ongoing Research Support
1.    Cyrus Research Scholar Award       Song(PI)                        07/11/2011 – 06/30/2014
Dysfunctional of TGF-β signaling via β2SP activates SOX9 and C-MYC via Notch signaling in Hepatocellular
Carcinoma; 
Role: Principal Investigator

2.    UTMDACC IRG                  Song(PI)                                  2012-2014    
Dysfunctional TGF- Signaling with Constitutively Active Notch Signaling Contributes to Barrett's Esophageal Adenocarcinoma   
Role: Principal Investigator

3.    Title:    Inhibition of Hedgehog Signaling in Gli-1 + Adeno CA
Funding Source:    NIH/NCI
Role:    Co-Investigator
Duration:    7/1/2013 - 6/30/2018
 
4.    Title:    Dual pathway inhibition in biomarker in esophageal cancer
Funding Source:    NIH/NCI
Role:    Co-Investigator
Duration:    4/1/2013 - 3/31/2018

Completed Research Support

1.    P30 DK056338 06 A3                     Song (PI)                           03/01/2010 – 02/28/2012
Texas Medical Center Digestive Disease Center (DDC)

The Role of Galectin-3 in Pancreatic Stromal-epithelial Interactions and Associated Tumor Fibrosis
The goal of this study is to determine the effects of galectin-3 on the activation of human pancreatic stellate
cells (HPSC) in vitro and in an orthotopic PaCa model and to identify the signaling mechanisms by which
galectin-3 activates HPSC and induces IL-8 in vitro. 
Role: Principal Investigator

2.    Research Scholar Award, AGA Foundation for Digestive Health and Nutrition;    2006-2010
The role of bile acids and Benzo(a)pyrene diol epoxide in the development of esophageal adenocarcinoma
The major aim of this project is to identify the possible mechanistic link between two known risk factors, bile
reflux and tobacco smoke, in the development of Barrett's esophageal adenocarcinoma. 
Role: Principal Investigator

3.    2 P30 DK056338 06                Song (PI)                             03/01/2008-02/28/2010
Texas Medical Center Digestive Disease Center (DDC)
The role of bile acids in the development of esophageal adenocarcinoma
The goal of this study is to determine the effects of bile acids, the major components of bile reflux in
esophagus on ectopic expression of MUC2 and MUC5AC, markers for Barrett' phenotype and to determine
effects of bile acids on the activation of oncogenic signalings in esophageal adenolcarcinoma cells.
Role: Principal Investigator
4.    Title:    Mucin glycoproteins in colorectal cancer metastasis
Funding Source:    NIH/NCI
Role:    Investigator
9/1/2006-8/1/2011