About the Journal of Neurological Research and Therapy
Advancing mechanistic understanding of nervous system pathophysiology through rigorous peer-reviewed research-from molecular pathways to biomarker discovery
JNRT provides a specialized forum for researchers investigating the fundamental mechanisms underlying neurological disorders. Unlike clinically-focused journals, we prioritize studies that elucidate molecular pathways, identify biomarkers, characterize disease models, and advance mechanistic hypotheses about nervous system pathology.
- Mechanistic Focus: Dedicated platform for pathway analysis, molecular targets, and disease mechanism studies
- Rigorous Peer Review: Expert evaluation by researchers specializing in neurological pathophysiology and molecular neuroscience
- Global Accessibility: Open access ensures worldwide visibility for your mechanistic discoveries
- Rapid Publication: Efficient workflows accelerate dissemination of time-sensitive mechanistic findings
- Interdisciplinary Integration: Bridge molecular biology, systems neuroscience, genetics, and translational pathophysiology
- Comprehensive Indexing: Enhanced discoverability through multiple academic databases and search platforms
JNRT publishes research that advances mechanistic understanding of how neurological diseases develop and progress. Our scope encompasses molecular, cellular, and systems-level investigations that reveal the biological foundations of nervous system disorders.
Signal transduction cascades, gene expression regulation, protein-protein interactions, post-translational modifications, and molecular drivers of disease progression
Identification of molecular signatures, fluid biomarkers, imaging markers, genetic risk variants, and mechanistic indicators of disease states
Neuronal dysfunction, glial cell contributions, synaptic pathology, neurotransmitter alterations, and cell-cell communication disruption
In vitro models, animal models, organoid systems, computational modeling, and experimental platforms for mechanistic investigation
Mutation analysis, genome-wide associations, chromatin modifications, DNA methylation, and gene-environment interactions in disease pathogenesis
Immune cell activation, cytokine signaling, complement pathways, microglial responses, and inflammatory cascades in neurological disease
Energy metabolism disruption, oxidative phosphorylation defects, ROS generation, calcium dysregulation, and metabolic pathway alterations
Misfolding mechanisms, aggregate formation, autophagy dysfunction, proteasomal degradation, and protein quality control pathways
JNRT publishes mechanistic research on diverse neurological disorders affecting the central and peripheral nervous system:
Neurodegenerative Diseases: Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, prion diseases, and related neurodegenerative pathologies
Demyelinating Disorders: Multiple sclerosis, neuromyelitis optica, acute disseminated encephalomyelitis, and other white matter pathologies
Epilepsy & Seizure Disorders: Epileptogenesis mechanisms, seizure propagation pathways, channelopathies, and synaptic hyperexcitability
Cerebrovascular Pathology: Ischemic injury mechanisms, hemorrhagic stroke pathophysiology, blood-brain barrier disruption, and vascular contributions to neurodegeneration
Peripheral Neuropathies: Axonal degeneration, demyelination mechanisms, metabolic neuropathy pathogenesis, and hereditary neuropathy molecular basis
Neurodevelopmental Disorders: Cerebral palsy pathophysiology, autism spectrum disorder mechanisms, attention disorders, and developmental pathway disruption
Movement Disorders: Basal ganglia circuit dysfunction, dystonia mechanisms, tremor pathophysiology, and motor system pathology
Nuropsychiatric Mechanisms: Depression neurobiology, anxiety pathways, schizophrenia pathophysiology (mechanistic aspects only)
JNRT accepts diverse article formats that advance mechanistic understanding of neurological pathophysiology:
JNRT employs a streamlined submission workflow designed to efficiently evaluate mechanistic rigor while maintaining scholarly standards. Authors submit manuscripts via our online submission system or by email to [email protected].
Authors should consult our Instructions for Authors to ensure compliance with formatting requirements, reporting standards (ARRIVE, MIQE, etc.), and ethical guidelines for animal and human subjects research.
Representative articles demonstrating JNRT's commitment to advancing mechanistic understanding of neurological disease:
JNRT operates under a transparent open access model with article processing charges (APCs) applied only upon manuscript acceptance. This ensures global accessibility while supporting rigorous peer review, professional copyediting, and comprehensive indexing.
Authors retain copyright under CC BY 4.0 licensing, enabling unlimited reuse, adaptation, and redistribution with appropriate attribution. This maximizes the impact of mechanistic discoveries by facilitating integration into teaching materials, grant applications, and derivative research.
Advance Neurological Science Through Mechanistic Discovery
Submit your research to JNRT and contribute to the mechanistic understanding of neurological disease. Join a community of investigators unraveling the molecular and cellular foundations of nervous system disorders.
